If something else causes your platelet count to be high, such as an infection or operation, this is known as reactive thrombocytosis. Generally they only occur with a platelet count over 1000 million per ml, and only in the presence of other risk factors such as dehydration.
In this way, what causes platelet count to be high?
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. If you have thrombocytosis caused by a bone marrow disorder (essential thrombocythemia), your bone marrow overproduces the cells that form platelets (megakaryocytes), releasing too many platelets into your blood.
What is the treatment for high platelets?
Currently, hydroxyurea plus aspirin is the standard treatment for people who have primary thrombocythemia and are at high risk for blood clots. Anagrelide. This medicine also has been used to lower platelet counts in people who have thrombocythemia.
A platelet count is used to detect the number of platelets in the blood. The test is included in a complete blood count (CBC), a panel of tests often performed as part of a general health examination. Platelets are tiny fragments of cells that are essential for normal blood clotting.
Plavix does indeed cause you to have a low platelet count. This is also called thrombocytopenia and is the common effect of taking a "blood thinner" type medication. This is not really a side effect - it is the whole reason why you would take Plavix in the first place.
Essential thrombocythemia (ET) is one of a related group of blood cancers known as “myeloproliferative neoplasms” (MPNs) in which cells in the bone marrow that produce the blood cells develop and function abnormally. ET does not generally shorten life expectancy.
Although there's no cure for essential thrombocythemia, there are treatments available. And, lifespan is expected to be normal despite the disease. Treatment of essential thrombocythemia depends on your risk of blood-clotting or bleeding episodes.
Essential thrombocythemia, also known as ET, is a rare disease. Common alternative causes of an elevated platelet count are iron deficiency, infection or generalized inflammation; less common causes are blood disorders such as ET or other related blood diseases (also see below).
Even though the platelet count is elevated for a short time (or even indefinitely after splenctomy), secondary thrombocytosis does not typically lead to abnormal blood clotting. Primary thrombocytosis, or essential thrombocythemia, can cause serious bleeding or clotting complications.
Essential thrombocythemia (ET) is a rare type of blood cancer. ET occurs when the body makes too many platelets, the part of the blood needed for clotting. ET is one of three myeloproliferative neoplasms (MPNs). There is no cure for ET but people with the disease often live normal lives.
In some cases, the patient can take aspirin to help prevent blood clots. The low dose used for this purpose does not usually cause stomach upset or bleeding. In essential thrombocythemia, drugs such as hydroxyurea or anagrelide are used to suppress platelet production by the bone marrow.
Low dose chemotherapy pills, such as hydrea, can be given to patients with essential thrombocythemia and polycythemia vera to lower their platelet and red blood cell counts. Phlebotomy (the removal of blood intravenously) is also an effective strategy for lowering red blood cell counts and controlling symptoms.
Myeloproliferative disorders are slow acting, and don't always cause life-threatening symptoms. The complications of these conditions, however, may be serious. Some complications include: Enlargement of the spleen and liver.
Myeloproliferative diseases (MPDs) are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. Chronic myelogenous leukemia (CML), shown in the image below. Polycythemia vera (PV)
Myeloproliferative neoplasms are a group of rare disorders of the bone marrow that cause an increase in the number of blood cells. Myeloproliferative neoplasm is a term that doctors use both for cancers (malignant neoplasms) and non cancerous tumours (benign neoplasms).
MPN Symptoms. Some people with myeloproliferative neoplasms (MPN) have no symptoms when their disease is diagnosed. But a routine blood test may show high levels of red blood cells, white blood cells, or platelets. Other people with MPN may have general symptoms, such as fever, night sweats, and weight loss.
Normally, the marrow produces only enough new cells to replace the ones that have died. However, in polycythemia vera new blood cells are produced in excess. If left untreated, polycythemia vera may be fatal; stroke and heart attack are the most common causes of death.
Hereditary myeloproliferative disorders. In contrast, the primary defect that underlies the second category of hereditary MPD, i.e. the inherited predisposition to MPD that frequently comes with a somatic JAK2-V617F mutation,13 remains to be defined.
Primary myelofibrosis also causes thickening or scarring of the fibers inside bone marrow, which can decrease the production of red blood cells and cause anemia. Polycythemia Vera (PV) is caused by the overproduction of red blood cells in the bone marrow, which then build up in the blood.
It's a blood cancer that begins in the marrow of your bones, the soft center where new blood cells grow. If you have polycythemia vera, your marrow makes too many red blood cells, which causes your blood to get too thick. That can make you more likely to have blood clots, a stroke, or a heart attack.
For example, untreated, polycythemia vera (PV) was initially thought to have a poor prognosis with a life expectancy of one to two years from the time of diagnosis. However, polycythemia vera prognosis is now greatly improved to 10-15 years survival after diagnosis with treatment by phlebotomy alone.
Common symptoms of polycythemia vera (PV) include:
- Tiredness (fatigue)
- Itching (especially after a warm shower)
- Sweating (at night or during the day)
- Blurred vision or blind spots.
- Painful burning or numbness of the hands or feet.
- Bleeding from the gums and heavy bleeding from small cuts.
- Bone pain.